Accelerating mRNA therapeutics with opDNA®: Faster, cleaner, and more efficient DNA synthesis

Plasmid DNA (pDNA) production faces significant challenges, including bacterial contamination, endotoxin removal, low yields with complex sequences, and scalability bottlenecks, all of which threaten the efficiency and consistency of mRNA manufacturing.

These limitations have sparked growing interest in synthetic DNA as a more efficient and reliable alternative. 4basebio’s opDNA® synthetic DNA template addresses these issues by eliminating the reliance on bacterial systems, offering a cleaner, faster, and more scalable solution for mRNA production. The rapid, enzymatic manufacturing process of opDNA® simplifies the complex processes involved in pDNA manufacturing, enabling the next generation of mRNA therapies.